From Los Angeles:
Take U.S. Highway 101 North. Travel time is approximately 3 1/2 hours.
From San Francisco:
Take U.S. Highway 101 South. Travel time is approximately 4 hours. For a more scenic but less direct route, take Highway 1 south from San Francisco and add 60 to 90 minutes to your estimated travel time.
From the Central Valley:
Take State Route 46 or 41 to Paso Robles and then down U.S. Highway 101 South.
San Luis Obispo is
- 106 miles from Santa Barbara
- 135 miles from Monterey
- 141 miles from Bakersfield
- 148 miles from Fresno
- 198 miles from Los Angeles
- 226 miles from San Francisco
- 310 miles from Sacramento
- 325 miles from San Diego