From Los Angeles:
Take U.S. Highway 101 North. Travel time is approximately 3 1/2 hours.

From San Francisco:
Take U.S. Highway 101 South. Travel time is approximately 4 hours. For a more scenic but less direct route, take Highway 1 south from San Francisco and add 60 to 90 minutes to your estimated travel time.

From the Central Valley:
Take State Route 46 or 41 to Paso Robles and then down U.S. Highway 101 South.

San Luis Obispo is

  • 106 miles from Santa Barbara
  • 135 miles from Monterey
  • 141 miles from Bakersfield
  • 148 miles from Fresno
  • 198 miles from Los Angeles
  • 226 miles from San Francisco
  • 310 miles from Sacramento
  • 325 miles from San Diego